Effects of dl-para-chlorophenylalanine on sucrose preference and intake: Reversal by 5-hydroxytryptophan and 6-methoxy 1,2,3,4,-tetrahydro-β-carboline

Add time:08/22/2019    Source:sciencedirect.com

In two experiments involving 12- or 4-hr two-bottle preference tests, rats depleted of brain serotonin by dl-para-chlorophenylalanine (pCPA) injections consumed larger amounts of sucrose and had a higher preference for sucrose solutions over distilled water than vehicle-injected control animals. Injection of 5-hydroxytryptophan (5-HTP) or 6-methoxy-1,2,3,4-tetrahydro-β-carboline (6-MeO-THBC) was found to reverse the effects of pCPA on brain serotonin as well as reverse the increased sucrose preference produced by pCPA.

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