Original articleCardioprotective effect of N-METHYLNICOTINAMIDE (cas 114-33-0) salt of pyruvate in experimental model of cardiac hypoxia
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Add time:08/21/2019 Source:sciencedirect.com
BackgroundPyruvate improves contractility of normal, hypoxic, and post-ischemic myocardium. However, sodium overload is a major problem with its therapeutic application if sodium pyruvate is used. Development of alternative forms such as N-1-methylnicotinamide (MNA) pyruvate may help to overcome this problem. The aim of the study was to investigate the effect of MNA pyruvate in a murine model of cardiac ischemia.
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