flavaspidic acid (cas 114-42-1): Effects on cell respiration and oxidative phosphorylation in isolated hepatocytes

Add time:08/23/2019    Source:sciencedirect.com

Flavaspidic acid-N-Methyl-glucaminate caused a concentration-dependent increase in oxygen consumption and decrease in ATP concentration, and an increased incorporation of 14C-oleate, 14C-octanoate and 14C-glucose into 14CO2 in isolated rat hepatocyte suspensions. Mitochondrial respiratory control ratio and P:O ratio were decreased by flavaspidic acid, indicating an uncoupling of oxidative phosphorylation. Although this agent remains a useful probe for the study of hepatic transport and metabolism of long chain fatty acids and other organic anions, conditions under which it is employed must be designed so as to avoid the potentially confusing effects of its adverse influence on cell energetics.

We also recommend Trading Suppliers and Manufacturers of flavaspidic acid (cas 114-42-1). Pls Click Website Link as below: cas 114-42-1 suppliers

Prev:flavaspidic acid (cas 114-42-1): A biochemical probe for the study of metabolic pathways in hepatocytes
Next:Studies of free and protein-bound β-flavaspidic acid (cas 114-42-1)-N-methylglucaminate in isolated rat hepatocytes and mitochondria☆)