Pyrrole alkaloids and ergosterols from Grifola frondosa exert anti-α-glucosidase and anti-proliferative activities

Add time:08/22/2019    Source:sciencedirect.com

Previously, polysaccharides with hypoglycemic effects from G. frondosa were reported by us. To explore compounds against α-glucosidase and human tumor cells, three extractive fractions (GF-1–GF-3) were prepared from G. frondosa ethanol extraction (GF) by chromatographic column. Rather than GF-1 and GF-2, the fraction GF-3 demonstrated inhibitory actions against α-glucosidase and proliferation of human tumor cells dominantly. To identify the bioactive compounds in GF-3, one new compound named pyrrolefronine together with 19 known ones, which included seven pyrrole alkaloids, nine ergosterols and three others, were isolated and characterized from GF-3. Significantly, pyrrole alkaloids were found in G. frondosa for the first time, showing potent inhibition against α-glucosidase. Obtained ergosterols displayed inhibition against proliferation of tumor cells. This study provides a basis for further development and utilization of G. frondosa as natural nutraceuticals and functional food ingredients.

We also recommend Trading Suppliers and Manufacturers of 1H-Pyrrole-2-carboxaldehyde,1-(hydroxymethyl)-(9CI) (cas 116967-16-9). Pls Click Website Link as below: cas 116967-16-9 suppliers

Prev:Ethnopharmacological communicationMacrophage activating activity of pyrrole alkaloids from Morus alba fruits
Next:Biosynthesis of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate by carbonyl reductase from Rhodosporidium toruloides in mono and biphasic media)