Research paperPyrimidine-chloroquinoline hybrids: Synthesis and antiplasmodial activity

Add time:08/25/2019    Source:sciencedirect.com

Triazole tethered 7-chloroquinoline-pyrimidine-5-carboxylate hybrids were synthesized and evaluated for antiplasmodial activity against chloroquine sensitive (CQS) NF54 strain of Plasmodium falciparum. The most active hybrids of the series were further screened against the chloroquine resistant (CQR) Dd2 strain of the parasite and for in vitro cytotoxicity against mammalian Vero cell lines. Further, their physico-chemical properties, binding studies with hemin (monomeric & μ-oxo dimeric) and DNA [pUC-18, calf thymus (CT)] led us to plausible proposed binding mode of the most active member of the present series.

We also recommend Trading Suppliers and Manufacturers of ETHYL-2-METHYL-4-PROPYL-5-PYRIMIDINE CARBOXYLATE (cas 127957-89-5). Pls Click Website Link as below: cas 127957-89-5 suppliers

Prev:Design, synthesis and pharmacological evaluation of pyrimidobenzothiazole-3-carboxylate derivatives as selective L-type calcium channel blockers
Next:Tetrahydro-1H,5H-pyrazolo[1,2-a]pyrazole-1-carboxylates as inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase)