Original articleSynthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives
-
Add time:08/23/2019 Source:sciencedirect.com
A series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety were synthesized and evaluated for antiproliferative activity against SW620, HT29 and MGC803 cancer cell lines in vitro. The pharmacological data demonstrated that the majority of target compounds exhibited moderate efficacy in HT29 and MGC803 cell lines. Compound 10c showed promising inhibition of hedgehog (Hh) signaling pathway in an Hh-related assay. In addition, the superposition pattern of 10c showed a good fit for a pharmacophoric model generated by Hh inhibitors and provided a basis for further structural optimization.
We also recommend Trading Suppliers and Manufacturers of 2-(TRIFLUOROMETHOXY)BENZAMIDE (cas 127979-74-2). Pls Click Website Link as below: cas 127979-74-2 suppliers
Prev:Original articleSynthesis and antitumor activities evaluation of m-(4-morpholinoquinazolin-2-yl)benzamides in vitro and in vivo
Next:The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Research paperDiscovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists08/27/2019
- N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2)08/26/2019
- Synthesis of benzamide derivatives as TRPV1 antagonists08/25/2019
- The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors08/24/2019
- Original articleSynthesis and antitumor activities evaluation of m-(4-morpholinoquinazolin-2-yl)benzamides in vitro and in vivo08/22/2019
- Design, synthesis and antiproliferative activity evaluation of m-(4-morpholinyl-1,3,5-triazin-2-yl)benzamides in vitro08/21/2019
