Synthesis of 1,3-diaryl-1H-benzo[g]indazoles
-
Add time:07/13/2019 Source:sciencedirect.com
A facile three-step synthetic route toward 1,3-diaryl-1H-benzo[g]indazoles 1a–1n starting with 3,4-dimethoxy-2-allylbenzaldehyde (6) in modest total yield is described. The facile route was carried by aldol condensation of aldehyde 6 with aryl methyl ketones 5a–5d in alkaline MeOH at reflux, Knorr pyrazole synthesis of the resulting chalcones 4a–4d with aryl hydrazines 3a–3e in EtOH at reflux followed by DDQ-mediated aromatization in toluene at reflux, and oxidative cleavage annulation of olefins 2a–2n with the one-pot combination of OsO4/NaIO4/HOAc in the aqueous THF at reflux.
We also recommend Trading Suppliers and Manufacturers of 5-AMINO-4-FLUORO 1H-INDAZOLE (cas 935250-69-4). Pls Click Website Link as below: cas 935250-69-4 suppliers
Prev:Discovery and preliminary structure–activity relationship of 1H-indazoles with promising indoleamine-2,3-dioxygenase 1 (IDO1) inhibition properties
Next:Synthesis of substituted 4-(1H-indol-6-yl)-1H-indazoles as potential PDK1 inhibitors) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- A novel three-component method for the synthesis of spiro[chromeno [4′,3′:4,5] pyrimido[1,2-b] indazole-7,3′-indoline]-2′,6(9H)-dione07/18/2019
- Novel 4-(3-phenylpropionamido), 4-(2-phenoxyacetamido) and 4-(cinnamamido) substituted benzamides bearing the pyrazole or indazole nucleus: synthesis, biological evaluation and mechanism of action07/17/2019
- Synthesis and antiproliferative activity of 3-amino-N-phenyl-1H-indazole-1-carboxamides07/16/2019
- A method for the regioselective synthesis of 1-alkyl-1H-indazoles07/15/2019
- Synthesis of substituted 4-(1H-indol-6-yl)-1H-indazoles as potential PDK1 inhibitors07/14/2019
- Discovery and preliminary structure–activity relationship of 1H-indazoles with promising indoleamine-2,3-dioxygenase 1 (IDO1) inhibition properties07/12/2019
- 4,6-Substituted-1H-Indazoles as potent IDO1/TDO dual inhibitors07/11/2019
