Facile synthesis of 3-(trifluoromethyl)adamantane derivatives

Add time:07/13/2019    Source:sciencedirect.com

A facile synthesis for 1-fluoro-3-(trifluoromethyl)adamantane, based on fluorination of 3-hydroxyadamantane-1-carboxylic acid, was developed. Its synthetic potentialities for preparation of (trifluoromethyl)adamantane derivatives containing diverse functional groups (acids, amines, etc.) in a bridgehead position, were disclosed.

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