Original articleSynthesis of N,N′-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinases

Add time:08/25/2019    Source:sciencedirect.com

The synthesis in 4 steps of new N,N′-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines issued from various symmetric primary diamines as linkers was reported. The key step of our strategy has been the sulphur/nitrogen displacement of (5Z)-5-arylidene-2-ethylsulfanyl-3,5-dihydro-4H-imidazol-4-ones 6 with respectively ethylenediamine 7a, piperazine 7b and N,N′-bis(3-aminopropyl)piperazine 7c using solvent-free reaction conditions under microwave irradiation with retention of configuration. These compounds were tested for their kinase inhibitory potencies toward four kinases (GSK-3α/β, DYRK1A, CLK1 and CLK3).

We also recommend Trading Suppliers and Manufacturers of N-(m-Benzyloxyphenyl)-alpha-piperidinoacetamide hydrochloride (cas 19515-41-4). Pls Click Website Link as below: cas 19515-41-4 suppliers

Prev:Synthesis and application of polymer-supported N-sulfonylated aminoalcohols as enantioselective catalysts
Next:Original articleSynthesis, antiviral activity, and 3D-QSAR study of novel chalcone derivatives containing malonate and pyridine moieties)