Preliminary communicationDesign and synthesis of novel 5,6-disubstituted pyridine-2,3-dione-3-thiosemicarbazone derivatives as potential anticancer agents

Add time:08/25/2019    Source:sciencedirect.com

A series of 5,6-disubstituted pyridine-2,3-dione-3-thiosemicarbazone derivatives(2a-2n) and 5,6-disubstituted pyridine-2,3-dione S-benzyl-3-thiosemicarbazones(3a-3g) were synthesized starting from 2,3-dihydroxypyridine via oxidation-Michael additions, condensations and nucleophilic substitutions. The structures of the compounds were established by IR, 1H NMR, 13C NMR, and HRMS. All newly synthesized compounds were screened for their anticancer activity against Breast cancer (MCF-7), Colon cancer (HCT-116) and hepatocellular cancer (BEL7402) cell lines. Bioassay results indicated that most of the prepared compounds exhibited cytotoxicity against various cancer cells in vitro. Some of the compounds exhibited promising antiproliferative activity, which were comparable to the positive control (5-fluorouracil). The structure–activity relationship was discussed.

We also recommend Trading Suppliers and Manufacturers of 5-bromo-2-(phenylthio)pyridine (cas 19520-27-5). Pls Click Website Link as below: cas 19520-27-5 suppliers

Prev:Original articleOptimization of 3-(phenylthio)quinolinium compounds against opportunistic fungal pathogens
Next:Sequential radical addition/cyclization/β-elimination reactions. 3-exo- and 5-exo-cycloaddition reactions of 5-phenylthio-3-pentenyl and 5-phenylthio-3-pentynyl radicals)