Regular paperInhibition of glycolysis in boar spermatozoa by 1,6-dichloro-1,6-dideoxy-D-fructose

Add time:08/29/2019    Source:sciencedirect.com

The dichloro-analogue of D-fructose 1,6-bisphosphate, 1,6-dichloro-1,6-dideoxy-D-fructose, is a weak substrate for boar sperm aldolase which converts it to (S)-3-chlorolactaldehyde and 3-chloro-l-hydroxypropanone in vitro. Production of these chloro-trioses leads to the strong inhibition of glyceraldehyde-3-phosphate dehydrogenase, the weak inhibition of triosephosphate isomerase and the transient inhibition of aldolase.

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