Asymmetric synthesis of (1R,2S)-2-fluorocyclopropylamine, the key intermediate of the new generation of quinolonecarboxylic acid, DU-6859

Add time:07/14/2019    Source:sciencedirect.com

The title synthesis was achieved by featuring diastereoface selective cyclopropanation of (4R,5S)-4,5-diphenyl-3-vinyl-2-oxazolidinone, the chiral and conformationally rigid N-vinylcarbamate, with zinc-monofluorocarbenoid followed by hydrogenolysis of formed (4R,5S)-3-[(1R-2S)-2-fluorocyclopropyl]-4,5-diphenyl-2-oxalidinone.

We also recommend Trading Suppliers and Manufacturers of (1R,2S)-(-)-2-AMINOCYCLOHEPTANECARBOXYLIC ACID HYDROCHLORIDE (cas 522644-07-1). Pls Click Website Link as below: cas 522644-07-1 suppliers

Prev:Enantioselective synthesis of (+)-(1R,2S)-allocoronamic acid
Next:Plasma and urine diketopiperazine concentrations in normal adults ingesting large quantities of aspartame)