BBA reportEffects of atriopeptin on particulate guanylate cyclase from rat adrenal

Add time:08/21/2019    Source:sciencedirect.com

Atriopeptin II activated particulate guanylate cyclase 5–10-fold in a concentration- and time-dependent fashion in crude membranes obtained from homogenates of rat adrenal cortex or medulla. Similar effects were observed with other atriopeptin analogs. Soluble guanylate cyclase and adenylate cyclase in these preparations were not activated. Accumulation of cyclic GMP in minces of adrenal cortex or medulla was increased 6–8-fold due to atriopeptin II activation of particulate guanylate cyclase. Several thiol-reactive agents blocked the activation of particulate guanylate cyclase, suggesting that free thiol groups on membrane proteins may be important in atriopeptin receptor-guanylate cyclase coupling.

We also recommend Trading Suppliers and Manufacturers of atriopeptin analog I (cas 117038-68-3). Pls Click Website Link as below: cas 117038-68-3 suppliers

Prev:Heterocyclizations of 2-aryl-3-arylamino-4,4,4-trifluoro-2-butenenitrile hydrates to 3-aryl-2-trifluoromethyl-4-quinolones and to 4-N-methylamino-3H-pyrazole-3-spiro-2′-(3′-aryl-3′-trifluoromethyl)oxiranes
Next:Atriopeptin and spontaneous hypertension in rats)