Original articleDesign and synthesis of pironetin analogue/COMBRETASTATIN A-4 (cas 117048-59-6) hybrids containing a 1,2,3-triazole ring and evaluation of their cytotoxic activity

Add time:08/26/2019    Source:sciencedirect.com

We here describe the preparation of a series of hybrid molecules containing a combretastatin A-4 moiety and a pironetin analogue fragment connected through a spacer of variable length which includes a 1,2,3-triazole ring. The cytotoxic activities of these compounds have been measured. Relations between structure and cytotoxicity are discussed. Some of the tested compounds showed cytotoxicity values of the same order of magnitude as combretastatin A-4 and were less toxic than the latter compound for normal cells.

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