5-Nitro-2-furyl derivative actives against Trypanosoma cruzi: Preliminary in vivo studies

Add time:07/14/2019    Source:sciencedirect.com

Ten 5-nitro-2-furyl derivatives, with good to excellent in vitro anti-Trypanosoma cruzi activity, and nifurtimox were tested oral and intraperitoneally on healthy animals for its acute toxicity on murine models. According to animals' survival percentage, organ histological results, biochemical and haematological findings, three new derivatives, with toxicity like nifurtimox, were selected to test in vivo as antichagasic agents. Clearly, dependences between chemical structure and both acute toxicity and in vivo anti-T. cruzi activity were observed. 4-Hexyl-1-[3-(5-nitro-2-furyl)-2-propenylidene]semicarbazide displayed good profile as anti-T. cruzi agent and better acute toxicity profile than nifurtimox.

We also recommend Trading Suppliers and Manufacturers of ethyl 5-{[5-(2-furyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}[1,2,3]triazolo[1,5-a]quinazoline-3-carboxylate (cas 667883-46-7). Pls Click Website Link as below: cas 667883-46-7 suppliers

Prev:Proton magnetic resonance studies of cyclic compounds—VI
Next:Novel copper(II) and palladium(II) complexes with 4-aroyl-5-pyrazolone ligands: Synthesis and characterization)