Research ArticlePharmaceutics, Drug Delivery and Pharmaceutical TechnologyA Study of FASORACETAM (cas 110958-19-5)’s Solid State Forms: A Potential Anti-Alzheimer Pharmaceutical

Add time:08/21/2019    Source:sciencedirect.com

Different solid state forms of the research chemical fasoracetam, which counters the effects of Alzheimer’s disease, have been subjected to a thermal and structural analysis. Single crystals were obtained from solution evaporation and from the melt. Single-crystal X-ray analyses of the crystals show the existence of 2 hydrated and 1 non-hydrated crystalline form of fasoracetam. Under ambient conditions, the hydrate form I is found to be the most stable form, showing a melting point of 57C. This low melting point, combined with possible water losses could cause problems when formulating the hydrated form and impact the storage conditions of the compound.

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