Comparative studies of the influence of cyclodextrins on the stability of the sunscreen agent, 2-ethylhexyl-p-methoxycinnamate

Add time:07/14/2019    Source:sciencedirect.com

The effects of β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) on the base-catalyzed degradation and light-induced decomposition of the sunscreen agent, trans-2-ethylhexyl-p-methoxycinnamate (trans-EHMC) were investigated. Reversed-phase liquid chromatography was used to study the interaction between natural and modified cyclodextrins, added to the mobile phase, and the sunscreen. Among the available cyclodextrins (β-CD, HP-β-CD, hydroxypropyl-α-cyclodextrin and hydroxypropyl-γ-cyclodextrin), only HP-β-CD and β-CD produced a significant decrease in the chromatographic retention of trans-EHMC. The complexation of the sunscreen agent with HP-β-CD and β-CD was confirmed by thermal analysis and nuclear magnetic resonance spectroscopy. β-CD depressed the decomposition of trans-EHMC in alkaline solutions more effectively than HP-β-CD. Moreover, the irradiation-induced degradation of the sunscreen agent in emulsion vehicles was reduced by complexation with β-CD (the extent of degradation was 26.1% for the complex compared to 35.8% for free trans-EHMC) whereas HP-β-CD had no significant effect. Therefore, the complex of β-CD with trans-EHMC enhances the chemical- and photo-stability of the sunscreen agent. Moreover, it limits adverse interactions of the UV filter with other formulation ingredients.

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