Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[11C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamine as a PET tracer for NR2B subunit-containing NMDA receptors

Add time:08/22/2019    Source:sciencedirect.com

IntroductionThe N-methyl-D-Aspartate (NMDA) receptor plays an important role in learning and memory. Overactivation is thought to play an important role in neurodegenerative disorders such as Alzheimer's disease. Currently, it is not possible to assess N-methyl-D-aspartate receptor (NMDAr) bio-availability in vivo. The purpose of this study was to develop a positron emission tomography (PET) ligand for the NR2B binding site of the NMDA receptor.

We also recommend Trading Suppliers and Manufacturers of N-[(4-methoxyphenyl)methyl]cyclopentanamine (cas 108157-23-9). Pls Click Website Link as below: cas 108157-23-9 suppliers

Prev:Subchapter 18A - Secretin
Next:ArticleThe Structural Basis for the Binding of Repaglinide (cas 108157-52-4) to the Pancreatic KATP Channel)