Synthesis and application of biocompatible gold core⿿poly-(l-Lysine) shell nanoparticles

Add time:08/26/2019    Source:sciencedirect.com

In this work, green synthesis of a kind of fluorescent core-shell nanoparticles via a facile one-pot method was reported. We chose tryptophan, a common amino acid, to serve as the green reducing agent of the gold core. And a biomacromolecule, poly-(l-lysine), was then employed to assemble and cross-link onto gold nanoparticle surfaces serving as the biocompatible shell. Fluorescence enhancement was observed after a cyanine dye was conjugated onto the nanoparticle surfaces. Then, peptides with arginine-glycine-aspartic acid sequence were bound to the shell as targeting ligand. Cell imaging assay demonstrated that the prepared nanoparticles are efficient in target sensing of integrin-positive cells. Moreover, they possess high biocompatibility because of the green synthetic method. Thus, the prepared nanoparticles show great potential in cellular imaging and targeted integrin detection.

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