Recent Developments in the Chemistry of Pyrido[1,2-a]pyrimidines

Add time:07/13/2019    Source:sciencedirect.com

Publisher SummaryPyrido[1,2-a]pyrimidines represent a simple bicyclic ring system that contains a nitrogen-bridgehead condensed pyrimidine moiety. Synthetic methods for these compounds can often be applied to the preparation of similar bi- and polycyclic ring systems. This chapter covers the primary chemical literature published between the second half of 1981 and 1993 and contained in Chemical Chemical Substance Indexes, Volumes 95-119 inclusive. The representatives of 4-oxo-4H-pyrido[1,2-a]pyrimidines, which exhibit valuable biological activities, have aroused much interest. Their pharmacological activities have been examined intensively, and the therapeutic effects of some of them have been demonstrated in clinics. Other representatives of 4H-pyrido[1,2-a]pyrimidines are used as photographic sensitizers, catalysts for curing polyisocyanates, or as dyes for acrylic nylon, polyester fibers, and photographic materials. The chapter further discusses the physicochemical and spectroscopic properties, syntheses, reactions, and more briefly, the utilization of pyrido[1,2-a]pyrimidines. It also reviews the pyrido[1,2-a]pyrimidines salts, the 2-oxo-2H-, 4-oxo-4H-, and then the 6-oxo-6H-pyrido[1,2-a]pyrimidines, followed by the 3,4-dihydro-2H-pyrido[1,2-a]pyrimidines, the 2-oxo-3,4-dihydro-2H- and 4-oxo-2,3-dihydro-4H-pyrido[1,2-a]pyrimidines, and finally pyrido[1,2-a]pyrimidines.

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