ArticlesSome Attempts to Prolong the Duration of Action of 2,2-DIETHYL-1,3-PROPANEDIOL (cas 115-76-4) (Prenderol®)
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Add time:08/23/2019 Source:sciencedirect.com
Although 2,a-diethyl-1,3-propanediol (Prenderol®) is a compound of pharmacologic interest, it is difficult to use clinically because of its short duration of action. A series of 23 compounds related to 2,2-DIETHYL-1,3-PROPANEDIOL (cas 115-76-4) and 2,2-diethyl malonic acid have been screened for anticonvulsant activity in mice in an attempt to find a drug with a longer duration of action. Of these, diethyl malonyl diurethane was the most interesting since it protected mice from the lethal and convulsant action of pentylenetetrazol for several hours. This effect was observed at doses which caused little observable change in the behavior of the mice. Higher doses caused clonic convulsions.
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