Development of a microporous membrane liquid–liquid extractor for organophosphate esters in human blood plasma: identification of triphenyl phosphate and octyl diphenyl phosphate in donor plasma

Add time:08/23/2019    Source:sciencedirect.com

An extractor has been developed for microporous membrane liquid–liquid extraction (MMLLE) of lipophilic xenobiotics at trace levels in biological fluids. This new construction allows the sample phase to be stirred, while the organic phase is pumped. The extractor was evaluated using human blood plasma with added organophosphate esters. The size exclusion properties of the membrane reduced lipid co-extraction by ∼94% compared to ordinary liquid–liquid extraction. In combination with a solid-phase extraction (SPE) step, the method was shown to remove plasma lipids efficiently and thus allow gas chromatographic separation of the compounds. The clean-up method described, including the SPE step, showed a high level of reproducibility, and recoveries of between 72 and 83% were obtained for five of the organophosphate esters after a 200-min extraction period. Using this technique, triphenyl phosphate and an isomer of octyl diphenyl phosphate were detected in human plasma obtained from blood donors. The concentration of triphenyl phosphate ranged between 0.13 and 0.15 μg/g plasma.

We also recommend Trading Suppliers and Manufacturers of diphenyl octyl phosphate (cas 115-88-8). Pls Click Website Link as below: cas 115-88-8 suppliers

Prev:Recovery of Th(IV) from leaching solutions of rare earth residues using a synergistic solvent extraction system consisting of Cyanex 572 and n-octyl diphenyl phosphate (ODP)
Next:Biological impact of octyl d-glucopyranoside based surfactants)