Research articleHealth and safety assessment and regulatory management of ALDICARB (cas 116-06-3), Atrazine, Diuron, Glyphosate, and MCPA by theoretical maximum daily intake estimation

Add time:08/28/2019    Source:sciencedirect.com

Management of pesticide standard values (PSVs) in different human exposure pathways is critical since pesticides may significantly impact human health from the exposure. Aldicarb, Atrazine, Diuron, Glyphosate, and MCPA are the five most widely used pesticides in the world. Many international jurisdictions have been working on regulating PSVs for these five pesticides. However, there is little agreement on PSVs among regulatory jurisdictions so far and most nations developed their PSVs without considering all the major exposure pathways. To make the PSVs more efficient in the protection of human health, theoretical maximum daily intake (TMDI) was introduced in this research to convert the PSVs into maximum mass loadings and evaluate the PSVs in a more comprehensive way. The computed TMDIs of these five pesticides vary from 4.45 to 6.75 orders of magnitude. For example, some nations only regulated the MCPA in one or two major exposures, and there are 87 computed TMDI values of MCPA (69.1% of the total) higher than the acceptable daily intake value of MCPA, indicating that those PSVs from major exposure pathways are not conservative enough in terms of protecting human health. Unless the TMDI values are computed based on the PSVs from all major exposure pathways, they might not be sufficient to protect human health from additional exposures.

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