Article2,5-Dihydropyrrole derivatives as enantiomerically enriched building blocks: Synthesis of the Geissman-Waiss lactone and polyhydroxylated pyrrolidines

Add time:08/25/2019    Source:sciencedirect.com

Starting from enantiomerically pure 2,5-dihydropyrroles substituted at 2-position, efficient stereoselective syntheses of the (+)-Geissman-Waiss lactone and of (+)-1,4,5-trideoxy-1,4-imino-D-ribo-hexitol hydrochloride have been achieved. This work illustrates the high potential of 2,5-dihydropyrroles for the obtention of polyhydroxylated nitrogen heterocycles.

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