Opposite action of oxytocin and its peptide antagonists on social memory in rats

Add time:08/22/2019    Source:sciencedirect.com

The synthetic 1-β,β-disubstituted analogues of [1-deamino]-oxytocin, [1′-(1′-thio-4′-methylcyclohexane)-acetic acid1]-oxytocin (MeCAOT) a peripheral oxytocin antagonist, and [1′-(1′-methyl-4′-thiopiperidine)-acetic acid1]-oxytocin (MePAOT), devoid of peripheral antioxytocin activity, were found to improve social memory of rats. The social memory in rats was disrupted by a wide range of doses of oxytocin (6–750 mU/kg) and this amnestic effect of oxytocin was antagonised by MePAOT and MeCAOT.

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