The first chemical synthesis of pyrazofurin 5′-triphosphate
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Add time:08/22/2019 Source:sciencedirect.com
As an archetype C-nucleoside, pyrazofurin possesses broad-spectrum antiviral and antitumor activities. However, the presence of the acidic enol in the nucleobase of pyrazofurin poses a huge challenge to the conventional NTP synthetic methods. On the basis of a selective phosphorylation method and the P(V)-N activation strategy, the first chemical synthesis of pyrazofurin 5′-triphosphate (PTP) was accomplished, which will greatly facilitate the investigation on the interactions of viral RNA polymerases and PTP, an important cellular metabolite of pyrazofurin.
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