Catalytic asymmetric synthesis of ethyl (1R,2S)-dehydrocoronamate

Add time:08/27/2019    Source:sciencedirect.com

A synthesis of (1R,2S)-dehydrocoronamic acid ethyl ester was developed employing a regio- and enantioselective palladium-catalysed nucleophilic ring-opening of 3,4-epoxy-1-butene with a glycine anion equivalent as the key enantiodifferentiating step. The desired selectivity was achieved using Trost’s naphthyl ligand. The subsequent activation of the free hydroxyl group and ring-closure by intramolecular SN2 reaction gave the desired amino acid ethyl ester.

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