Research paperAryl H-phosphonates. 19. New anti-HIV pronucleotide phosphoramidate diesters containing amino- and hydroxypyridine auxiliaries
-
Add time:08/22/2019 Source:sciencedirect.com
We have designed a new type of AZT and ddU phosphoramidate diesters containing various combinations of 2-, 3-, 4-aminopyridine and 2-, 3-, 4-hydroxypyridine moieties attached to the phosphorus center, as potential anti-HIV pronucleotides. Depending on the pKa values of the aminopyridines and the hydroxypyridines used, alternative synthetic strategies based on H-phosphonate chemistry were developed for their preparation. Synthetic aspects of these transformations and the biological activity of the synthesized compounds are discussed.
We also recommend Trading Suppliers and Manufacturers of D-A H-PHOSPHONATE) (cas 104684-74-4). Pls Click Website Link as below: cas 104684-74-4 suppliers
Prev:Quantum mechanical, spectroscopic and molecular docking studies of N-[4-cyano-3-(trifluoromethyl) phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
Next:DBU-promoted alkylation of alkyl phosphinates and H-phosphonates) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Sylilation of poly(alkylene H-phosphonate)s – Rapid and efficient method for obtaining poly(alkylene trisilylmethylphosphite)s08/27/2019
- Preparation, characterization and antioxidant activities of polymannuronic acid phosphate, H-phosphonate and sulfate08/26/2019
- I2O5/DBU mediated direct α-phosphoryloxylation of ketones with H-phosphonates leading to α-hydroxyketone phosphates08/25/2019
- Original articleAn H-phosphonate strategy for the synthesis of 2′,3′-dideoxynucleoside triphosphates and homodinucleotides08/24/2019
- DBU-promoted alkylation of alkyl phosphinates and H-phosphonates08/23/2019
