2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists

Add time:08/22/2019    Source:sciencedirect.com

We report the discovery and optimization of substituted 2-piperazinecarboxamides as potent and selective agonists of the melanocortin subtype-4 receptor. The 5- and 6-alkylated piperazine compounds exhibit low bioactivation potential as measured by covalent binding in microsome preparations.

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