Unusual reactivity of trifluoromethyl groups in meso-tetrakis(trifluoromethyl)porphyrin

Add time:07/13/2019    Source:sciencedirect.com

Based on the unusual reactivity of trifluoromethyl groups in nitrogen containing heterocycles, we synthesized the appropriate porphyrin mono-, di-, tri- or tetra-carboxylic ester derivatives by treatment of the precursor meso-tetrakis(trifluoromethyl)porphyrin with an excess of sodium- or potassium alkoxide in the respective alcohol. This method offers an efficient route for the synthesis of lower symmetry meso-substituted porphyrins compared to usual preparations utilizing stepwise condensation reactions. The structure of tetrakis(butyloxycarbonyl)porphyrin 5 was determined by X-ray analysis.

We also recommend Trading Suppliers and Manufacturers of 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-ol (cas 1119022-51-4). Pls Click Website Link as below: cas 1119022-51-4 suppliers

Prev:In vitro brain GABA-transaminase activity of 1-(4-acetylphenyl)-3-aryloxypyrrolidine-2,5-dione derivatives
Next:Novel tetracyclic benzo[b]carbazolones as highly potent and orally bioavailable ALK inhibitors: Design, synthesis, and structure—activity relationship study)