Synthesis and antibacterial evaluation of oxazolidin-2-ones structurally related to linezolid
-
Add time:08/27/2019 Source:sciencedirect.com
Compounds structurally related to the known antimicrobial drug linezolid were selected in order to evaluate the influence of electron-withdrawing properties and altered geometric features as a result of the N-substituent modification. After a preliminary study of molecular modeling, cinnamoyl-, pyridin- and pyrimidinoxazolidin-2-ones were synthesized. None of the new compounds showed antibacterial activity.
We also recommend Trading Suppliers and Manufacturers of (R)-4-(Hydroxymethyl)oxazolidin-2-one (cas 132682-23-6). Pls Click Website Link as below: cas 132682-23-6 suppliers
Prev:Direct synthesis of oxazolidin-2-ones from tert-butyl allylcarbamate via halo-induced cyclisation
Next:Polymer supported oxazolidin-2-ones derived from l-serine—a cautionary tale) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Total synthesis of (R)-(−)-actisonitrile via O-alkylation of optically active 4-hydroxymethyloxazolidin-2-one derivative09/01/2019
- Preliminary communicationSynthesis of 1-[3-(4-benzotriazol-1/2-yl-3-fluoro-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-3-substituted-thiourea derivatives as antituberculosis agents08/31/2019
- Novel enantiomerically pure 2-amino-1,4-diols from chiral 4-hydroxymethyl-5-iodo-1,3-oxazin-2-ones08/30/2019
- Regio- and stereoselective microwave-assisted synthesis of 5-alkyl-4-alkenyl-4-phenyl-1,3-oxazolidin-2-ones08/29/2019
- Polymer supported oxazolidin-2-ones derived from l-serine—a cautionary tale08/28/2019
- Direct synthesis of oxazolidin-2-ones from tert-butyl allylcarbamate via halo-induced cyclisation08/26/2019
- Quantitative ring contraction of 5-hydroxy-1,3-oxazin-2-ones into 5-hydroxymethyl-1,3-oxazolidin-2-ones: A DFT study08/25/2019
- Rearrangements and racemisation during the synthesis of l-serine derived oxazolidin-2-ones08/24/2019
- Synthesis of all four stereoisomers of 5-formyl-4-hydroxymethyl-1,3-oxazolidin-2-ones from d-glucosamine08/23/2019
