Bioactivity of a series of substituted N(3-phenyl-2-propenylidene)benzeneamines: a microcalorimetric study

Add time:07/15/2019    Source:sciencedirect.com

The interaction of some Schiff bases with Saccharomyces cerevisiae has been studied by microcalorimetry. Flow microcalorimetry is shown to yield accurate and precise measurements of the bioactivities of the study compounds. In addition, it has allowed the establishment of a structure-activity relationship (SAR) for these non-homologous Schiff bases. The data show that biologically based SARs may be general and of potential in establishing modes of action.

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