Oligomycins B and C: complete ab initio assignments of their 1H and 13C NMR spectra and a study of their conformations in solution

Add time:08/23/2019    Source:sciencedirect.com

Self-consistent, full assignments of the 1H and 13C NMR spectra are reported for the macrocyclic antibiotics oligomycin-B and -C. Solution conformations, deduced from proton–proton and proton–carbon-13 coupling constants as well as from chemical shift considerations, are compared with X-ray data. While coupling data are compatible with a fair degree of similarity between the overall conformations in the solid and solution states, small but definite differences are apparent in the “northern” part of the macrocycle (C-6 to C-12) of oligomycin-B. On the other hand, conformational differences, relative to the same region, have been detected between oligomycin-B and oligomycin-C in solution; this is likely due to steric crowding between bulky substiuents at C-9 and C-12 in oligomycin-B.

We also recommend Trading Suppliers and Manufacturers of 44-homooligomycin A (cas 132707-68-7). Pls Click Website Link as below: cas 132707-68-7 suppliers

Prev:Research articleSulfated pentagalloyl glucose (Y-ART-3) inhibits HIV replication and cytopathic effects in vitro, and reduces HIV infection in hu-PBL-SCID mice
Next:cis-2,6-Bis-(methanolate)-piperidine oxovanadium(V) complexes as catalysts for oxidative alkenol cyclization by tert-butyl hydroperoxide)