The ELAV family of RNA-binding proteins in synaptic plasticity and long-term memory

Add time:08/23/2019    Source:sciencedirect.com

The mechanisms of de novo gene expression and translation of specific gene transcripts have long been known to support long-lasting changes in synaptic plasticity and behavioral long-term memory. In recent years, it has become increasingly apparent that gene expression is heavily regulated not only on the level of transcription, but also through post-transcriptional gene regulation, which governs the subcellular localization, stability, and likelihood of translation of mRNAs. Specific families of RNA-binding proteins (RBPs) bind transcripts which contain AU-rich elements (AREs) within their 3′ UTR and thereby govern their downstream fate. These post-transcriptional gene regulatory mechanisms are coordinated through the same cell signaling pathways that play critical roles in long-term memory formation. In this review, we discuss recent results that demonstrate the roles that these ARE-binding proteins play in LTM formation.

We also recommend Trading Suppliers and Manufacturers of ELAV protein (cas 138391-28-3). Pls Click Website Link as below: cas 138391-28-3 suppliers

Prev:Research paperParicalcitol accelerates BACE1 lysosomal degradation and inhibits calpain-1 dependent neuronal loss in APP/PS1 transgenic mice
Next:ReviewELAV protein (cas 138391-28-3)s along evolution: Back to the nucleus?)