Replication of mitochondrial DNA: Selective inhibition of the H-strand synthesis in isolated mitochondria by Sibiromycin (cas 12684-33-2)
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Add time:08/27/2019 Source:sciencedirect.com
Sibiromycin, an antitumour antibiotic forming a stable complex with the double-stranded DNA selectively inhibits the incorporation of [3H]thymidine into the H-strand of mtDNA during the incubation of isolated rat liver mitochondria in vitro. A model accounting for this result is presented. It is concluded that the H-strand is a leading strand throughout mtDNA replication and consequently the replication of rat liver monomer mtDNA is unidirectional.
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