3-methoxy-4-aminoazobenzene (cas 80830-39-3), a selective inducer for a high spin form of cytochrome P-448 in rat liver microsomes

Add time:07/16/2019    Source:sciencedirect.com

Treatment of Splague Dawley rats with 3-methoxy-4-aminoazobenzene (3-MeO-AAB) resulted in striking increase of the activity of hepatic microsomal cytochrome P-450s which could efficiently catalyze the mutagenic activation of hepatocarcinogenic aromatic amines such as a tryptophan-pyrolysate component, Trp P-2, and a glutamic acid-pyrolysate component, Glu P-1. The 3-MeO-AAB-induced cytochrome P-450 (3-MeO-AAB-P-450) was examined for the molecular charactor by immuno-Western blotting using monoclonal antibody to 3-methylcholanthrene-induced cytochrome P-448 and was characterized as a high spin form of cytochrome P-448 (P-448H; m.w. 54,000).

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