New 5-arylamino-4-(5-nitrofuran-2-yl)pyrimidines as promising antibacterial agents

Add time:07/13/2019    Source:sciencedirect.com

A facile synthetic approach to 5-arylamino-4-(5-nitrofuran- 2-yl)pyrimidines by the Buchwald–Hartwig cross-coupling with various anilines has been developed. All synthesized compounds demonstrated a significant level of in vitro antibacterial activity against Neisseria gonorrhoeae, Streptococcus pyogene and Staphylococcus aureus, including their drug-resistant strains, which is much higher than that of the commercial drug Spectinomycin.

We also recommend Trading Suppliers and Manufacturers of ethyl 5-(furan-2-yl)-3-(5-nitrofuran-2-yl)-1,2-oxazole-4-carboxylate (cas 22996-54-9). Pls Click Website Link as below: cas 22996-54-9 suppliers

Prev:Synthesis and evaluation of N-substituted 2-amino-4,5-diarylpyrimidines as selective adenosine A1 receptor antagonists
Next:Investigating the structure-activity relationships of N’-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against Trypanosoma cruzi to design novel active compounds)