Sensitivity of fibroblasts derived from ataxia-telangiectasia patients to calicheamicin γ1I
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Add time:08/24/2019 Source:sciencedirect.com
We report the hypersensitivity of SV40-transformed fibroblasts derived from ataxia telangiectasia (AT) patients to calicheamicin γ1I. In common with other free-radical generating agents such as bleomycin and ionizing radiation, treatment with calicheamicin γ1I reveals AT derived lines to be 6-fold more sensitive to this drug when compared to controls. Furthermore, in common with ionizing radiation, AT cells did not show dose-dependent inhibition of DNA synthesis after treatment with calicheamicin γ1I
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