Short communicationEffect of Pancuronium bromide (cas 15500-66-0) on the adrenergic reactivity of the isolated rat vas deferens

Add time:08/27/2019    Source:sciencedirect.com

Pancuronium bromide (cas 15500-66-0) (10−7 to 10−4 M) failed to produce contraction of the isolated rat vas deferens. Also, no contractions were seen when the animals were pretreated with an MAO inhibitor (iproniazid 80 mg/kg, p.o.). On the other hand, pancuronium bromide (10−6 to 10−4 M) produced 1.62- to 2.65-fold increases in the sensitivity of the vas deferens to noradrenaline. This rules out an indirect adrenergic effect in this preparation and suggests an inhibitory effect on catecholamine uptake.

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