Synthesis of 5-alkyl-2-amino-1,3,4-thiadiazoles and α,ω-bis(2-amino-1,3,4-thiadiazol-5-yl)alkanes in ionic liquids

Add time:07/13/2019    Source:sciencedirect.com

Reaction of thiosemicarbazide with carboxylic acids, including N-substituted amino acids, in ionic liquids with H2SO4 as a catalyst affords 5-R-2-amino-1,3,4-thiadiazoles. On using alkanedicarboxylic acids, α,ω-bis(2-amino-1,3,4,-thiadiazol-5-yl)alkanes were obtained.

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