Cellular and Molecular NeuroscienceResearch PaperLeu27 insulin-like growth factor-II, an insulin-like growth factor-II analog, attenuates depolarization-evoked GABA release from adult rat hippocampal and cortical slices
-
Add time:08/25/2019 Source:sciencedirect.com
Accumulated evidence suggests that the single transmembrane domain insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-II/M6P or IGF-II receptor) plays an important role in the intracellular trafficking of lysosomal enzymes and endocytosis-mediated degradation of insulin like growth factor (IGF-II). However, the role of this receptor in signal transduction following IGF-II binding remains controversial. In the present study, we revealed that Leu27IGF-II, an analog which binds preferentially to the IGF-II receptor, can attenuate K+-as well as veratridine-evoked GABA release from the adult rat hippocampal formation. Tetrodotoxin failed to alter the effects of Leu27IGF-II on GABA release, thus suggesting the lack of involvement of voltage-dependent Na+ channels. Interestingly, the effect is found to be sensitive to pertussis toxin (PTX), indicating the possible involvement of a Gi/o protein-dependent pathway in mediating the release of GABA from the hippocampal slices. Additionally, Leu27IGF-II was found to attenuate GABA release from frontal cortex but not from striatum. These results, together with the evidence that IGF-II receptors are localized on GABAergic neurons, raised the possibility that this receptor, apart from mediating intracellular trafficking, may also be involved in the regulation of endogenous GABA release by acting directly on GABAergic terminals.
We also recommend Trading Suppliers and Manufacturers of insulin-like growth factor II, Leu(27)- (cas 132729-29-4). Pls Click Website Link as below: cas 132729-29-4 suppliers
Prev:Characterizing the complexity of Australian marsupial insulin-like growth factor 1 genes
Next:Dung-shen (Codonopsis pilosula) attenuated the cardiac-impaired insulin-like growth factor II receptor pathway on myocardial cells) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Gene wiki reviewNuclear actions of insulin-like growth factor binding protein-309/02/2019
- Plasma levels of insulin-like growth factor-I, insulin-like growth factor binding protein-1, coenzyme Q10 and vitamin E in female populations from Poland, Serbia and Sweden09/01/2019
- ArticleAutocrine Insulin-Like Growth Factor II Inhibits β-Casein mRNA Expression in a Mammary Cell Line108/31/2019
- ReviewNeurodevelopmental effects of insulin-like growth factor signaling08/30/2019
- Mapping of the insulin-like growth factor II binding site of the Type I insulin-like growth factor receptor by alanine scanning mutagenesis08/29/2019
- Maternal Insulin-like Growth Factor-II Promotes Placental Functional Development Via the Type 2 IGF Receptor in the Guinea Pig08/28/2019
- Effects of dietary leucine levels on growth, feed utilization, neuro-endocrine growth axis and TOR-related signaling genes expression of juvenile hybrid grouper (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂)08/27/2019
- Dung-shen (Codonopsis pilosula) attenuated the cardiac-impaired insulin-like growth factor II receptor pathway on myocardial cells08/26/2019
- Characterizing the complexity of Australian marsupial insulin-like growth factor 1 genes08/24/2019
