Short communicationSynthesis and renal vasodilator activity of substituted [4-alkyl(aryl)quinazolin-2-one-1-yl]alkanoic acids

Add time:08/25/2019    Source:sciencedirect.com

The synthesis and cardiovascular evaluation of a novel series of [4-alkyl(aryl)quinazolin-2-one-1-yl]alkanoic esters and acids (II) as renal vasodilators is presented. The compound 3-[6,7-dihydroxy-4-methyl-(1H)-quinazoline-2-one-1-yl]propanoic acid (7) was found to be a potent and selective renal vasodilator.

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