Probing membrane permeabilization by the antibiotic lipopeptaibol trichogin GA IV in a tethered bilayer lipid membrane
-
Add time:08/27/2019 Source:sciencedirect.com
The lipopeptaibol trichogin GA IV (TCG) can be incorporated in the lipid bilayer moiety of a mercury-supported tethered bilayer lipid membrane (tBLM) at a non-physiological transmembrane potential of about − 240 mV, negative on the trans side of the bilayer. Once incorporated in the tBLM, TCG is stable over the range of physiological transmembrane potentials and permeabilizes the membrane at transmembrane potentials negative of − 80 ÷ − 90 mV. The chronocoulometric behavior is consistent with a kinetics of nucleation and growth of bundles of TCG building blocks with ion-channel properties. The TCG building blocks also permeabilize the lipid bilayer, albeit at more negative transmembrane potentials, and can be tentatively regarded as dimers of aligned TCG helical monomers. The cyclic voltammograms of tBLMs incorporating TCG point to a voltage-gated behavior of the TCG channel, similar to that exhibited by the peptaibol alamethicin.
We also recommend Trading Suppliers and Manufacturers of trichogin A IV (cas 138531-93-8). Pls Click Website Link as below: cas 138531-93-8 suppliers
Prev:Data articleComparison of bactericidal and cytotoxic activities of trichogin analogs
Next:Molecular resolution visualization of a pore formed by trichogin, an antimicrobial peptide, in a phospholipid matrix) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Aggregation and Water-Membrane Partition as Major Determinants of the Activity of the Antibiotic Peptide Trichogin GA IV09/02/2019
- Location and Aggregation of the Spin-Labeled Peptide Trichogin GA IV in a Phospholipid Membrane as Revealed by Pulsed EPR09/01/2019
- Mechanism of Membrane Activity of the Antibiotic Trichogin GA IV: A Two-State Transition Controlled by Peptide Concentration08/31/2019
- Ion transport across a phospholipid membrane mediated by the peptide trichogin GA IV08/30/2019
- Membrane thickness and the mechanism of action of the short peptaibol trichogin GA IV08/29/2019
- Molecular resolution visualization of a pore formed by trichogin, an antimicrobial peptide, in a phospholipid matrix08/28/2019
- Data articleComparison of bactericidal and cytotoxic activities of trichogin analogs08/26/2019
- The peculiar N- and C-termini of trichogin GA IV are needed for membrane interaction and human cell death induction at doses lacking antibiotic activity08/25/2019
- Peptide antibiotic trichogin in model membranes: Self-association and capture of fatty acids08/24/2019
