Design and synthesis of novel leucomycin analogues modified at the C-3 position. Part II: 3-O-(3-Aryl-2-propenyl)leucomycin analogues

Add time:08/27/2019    Source:sciencedirect.com

The design and synthesis of 16-membered macrolides modified at the C-3 position are described. Starting from fully protected intermediate (5), appropriate modifications including Heck reaction were performed to furnish 3-O-(3-aryl-2-propenyl)leucomycin A7 analogues (9a–9m). These leucomycin A7 derivatives showed improved in vitro antibacterial activities against clinically important pathogens including erythromycin-resistant Streptococcus pneumoniae (ERSP). SAR analysis of derivatives modified at the C-3 and C-3″ positions suggested that single modification at C-3 or C-3″ was effective for in vitro antibacterial activity.

We also recommend Trading Suppliers and Manufacturers of α-Methyl-4-[4-(2-propenyl)-2-thiazolyl]benzeneacetic acid (cas 138568-64-6). Pls Click Website Link as below: cas 138568-64-6 suppliers

Prev:Copolymers from tert-butyl methacrylate and 2-propenyl isocyanate—polymers for photoresist application
Next:Synthesis of a fully protected (2S,3R)-N-(1′,1′-dimethyl-2′- propenyl)-3-hydroxytryptophan from tryptophan)