Two novel anthraquinones with cytotoxicity from Hedyotis caudatifolia
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Add time:08/25/2019 Source:sciencedirect.com
Seven anthraquinones, including two new natural products, hedyanthraquinones A and B (1, 2), were isolated from Hedyotis caudatifolia. The structures were elucidated based on NMR, MS data and physico-chemical properties. Compounds 1 and 2 displayed moderate cytotoxic activities against a panel of cultured tumor cell lines (HL-60, Bcap37, SMMC7721) with IC50 values of 13.71 ∼ 26.29 μM. The result showed that anthraquinones are typical compounds of Hedyotis genus, which could be useful as characteristic markers in chemotaxonomic research and might helpful for explaining the use of H. caudatifolia in Traditional Chinese Medicine.
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