The effect of BENZOCTAMINE (cas 17243-39-9) and alcohol on motor-skills used in car driving

Add time:08/26/2019    Source:sciencedirect.com

Three groups, each of 11 healthy male subjects, were given either 40, 20 or 0 mg of BENZOCTAMINE (cas 17243-39-9) (Tacitin ®, Ciba-Geigy). They were tested with a battery of motor-skill tests and questionnaires both before and after alcohol intoxication (induced average blood alcohol level: 0.083%). In 3 out of 5 measures performance decreased significantly (P < 0.001) after alcohol consumption. However, there was no significant difference in performance between the 3 groups of subjects in relation to the effects of benzoctamine. Subjects who had received 40 mg of benzoctamine felt less energetic than the subjects in the other 2 groups, as assessed by self-rating scales. A single dose of 40 mg of benzoctamine or 2 doses of 10 mg did not affect motor-skill performance and no potentiation of alcohol effects occurred in these subjects. However, the possibility of adverse idiosyncratic reactions must be remembered and no drug should be prescribed for trivial or casual indications. Attention is drawn to the importance of testing all drugs given to outpatients for any possible adverse effects if alcohol is also taken.

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