One-pot synthesis of 2-trifluoromethyl and 2-difluoromethyl substituted benzo-1,3-diazoles

Add time:08/28/2019    Source:sciencedirect.com

2-Trifluoromethyl and 2-difluoromethyl substituted benzimidazole, benzoxazole and benzothiazole derivatives were efficiently prepared through a one-pot reaction of trifluoroacetic acid and difluoroacetic acid, respectively, with commercially available o-phenylenediamines, 2-aminophenols, and 2-aminobenzenethiols in good to excellent yields. Subsequential bromination of 2-difluoromethyl groups by photolysis with NBS led to the formation of bromodifluoromethyl benzo-1,3-diazoles which may be utilized to prepare the new generation of gem-difluoromethylene linked identical or non-identical twin molecules for drug synthesis.

We also recommend Trading Suppliers and Manufacturers of 2-(difluoromethylene)-4,4,5-trifluoro-5-(trifluoromethyl)-1,3-dioxolane (cas 17256-52-9). Pls Click Website Link as below: cas 17256-52-9 suppliers

Prev:Difluoromethylene compounds as precursors to ketones, carboxylic acids, esters, amides and carbonates
Next:Synthesis and characterization of new hydroxylammonium fluoromanganates and fluoroscandates)