ArticlesThe Pharmacology of 1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol Methsulfate, Compound 14045, a New Parasympathetic Depressant*

Add time:08/26/2019    Source:sciencedirect.com

1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol methsulfate has been found to be a drug which possesses marked anticholinergic activity. This was particularly true for the gastrointestinal tract of anesthetized or trained animals. It also is shown to have pharmacological properties similar to many of the atropine substitutes. It inhibited gastric and salivary secretions and caused dilatation of the pupils. With relatively high doses sympathetic ganglionic blockade and a curare-like paralysis could be demonstrated. Toxicity studies indicated that the drug was much more toxic by vein than atropine but about equally toxic by mouth. Three-month subacute toxicity studies revealed the drug to be well tolerated by rats and dogs.

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