Original articleProtective Effect of Diindolylmethane against N-Butyl-N-(4-hydroxybutyl) Nitrosamine-induced Bladder Carcinogenesis

Add time:08/25/2019    Source:sciencedirect.com

BackgroundCarcinogenesis involves three distinguishable stages, namely, initiation, promotion, and progression. Chemoprevention is the use of agents to inhibit, reverse, or retard tumorigenesis at the initiation stage itself. Diindolylmethane (DIM) is one such agent. The precursor of DIM, that is, indole-3-carbinol, has been found to have beneficial effects in the treatment of prostate and breast cancers. This study was designed to evaluate the protective role of DIM in bladder carcinogenesis. N-Butyl-N-(4-hydroxybutyl) nitrosamine (BBN) was used as a carcinogen to study the chemopreventive activity of DIM in bladder carcinogenesis.

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