Chapter 28 - Polycyclic compounds comprising a pyridine and two or more carbocyclic rings

Add time:08/27/2019    Source:sciencedirect.com

Publisher SummaryThis chapter deals with the acridine and phenanthridine systems, and a number of less well studied mono-aza-polybenzenoid structures. The main current scientific interest in these compounds lies in their carcinogenicity. Their biological activity and that of the carcinogens and mutagens derived from them have been recently reviewed. The extent of this carcinogenicity has also been paralleled with carbon-13 nuclear magnetic resonance properties and with electronic properties and with theoretical reactivity indices. The present focus upon the formation of such polybenzenoid compounds and their heterocyclic analogues by the pyrolysis of tobacco leaf proteins and other vegetable matter, and the improvements in the analytical techniques for the identification of these compounds, has led to many compounds being identified, which otherwise would not have been included in this review. The recently reported syntheses have usually followed a few well-tried sequences. New synthetic methods, or those of particular interest, are discussed for the compounds—namely, acridine, phenanthridine, benzoquinolines, benzisoquinolines, benzacridines, benzophenanthridines, dibenzoquinolines, dibenzacridines, napthoquinolines and naphthisoquinolines, azafluoranthenes, and larger aza-arenes with structure and illustrations.

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